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DAG1 rabbit pAb

CAT: 0855-ES8965-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8965-01Size:50 µL
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Background
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Description
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015],
UniProt
Q14118
Swiss Prot
Q14118
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 830-910
Target
DAG1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
98kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
98kD
Fragment
IgG
Subcellular Location
[Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane ; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm . Cell membrane, sarcolemma . Cell junction, synapse, postsynaptic cell membrane . The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity) . In peripheral nerves, localizes to the Schwann cell membrane. Colocal
Gene ID (Human)
1605

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