C1RL rabbit pAb

• Background:

  Caution:Does not associate with the C1 complex. According to PubMed:15385675 doesn't cleave the proform of complement C1s., function:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum., induction:Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 CUB domain., similarity:Contains 1 peptidase S1 domain., tissue specificity:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level) .

• Description:

  Caution: Does not associate with the C1 complex. According to PubMed: 15385675 doesn't cleave the proform of complement C1s. function: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. induction: Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation. similarity: Belongs to the peptidase S1 family. similarity: Contains 1 CUB domain. similarity: Contains 1 peptidase S1 domain. tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).

• UniProt:

  Q9NZP8

• Swiss Prot:

  Q9NZP8

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human C1RL. at AA range: 371-420

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight:

  53kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  53kD

• Fragment:

  IgG

• Subcellular Location:

  Secreted .

• Other Product Names:

  Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)

• Gene ID (Human):

  51279