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C1RL rabbit pAb

CAT: 0855-ES8873-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8873-01Size:50 µL
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Background
Caution:Does not associate with the C1 complex. According to PubMed:15385675 doesn't cleave the proform of complement C1s., function:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum., induction:Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 CUB domain., similarity:Contains 1 peptidase S1 domain., tissue specificity:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level) .
Description
Caution: Does not associate with the C1 complex. According to PubMed: 15385675 doesn't cleave the proform of complement C1s. function: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. induction: Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation. similarity: Belongs to the peptidase S1 family. similarity: Contains 1 CUB domain. similarity: Contains 1 peptidase S1 domain. tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).
Product Name Alternative
Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)
UniProt
Q9NZP8
Swiss Prot
Q9NZP8
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human C1RL. at AA range: 371-420
Target
C1RL
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
53kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
53kD
Fragment
IgG
Subcellular Location
Secreted .
Other Product Names
Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)
Gene ID (Human)
51279

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