Thioredoxin rabbit pAb

• Background:

  The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Description:

  The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• Synonyms:

  Thioredoxin (Trx;ATL-derived factor;ADF;Surface-associated sulphydryl protein;SASP)

• Gene ID:

  7295

• UniProt:

  P10599

• Cellular Locus:

  Nucleus. Cytoplasm. Secreted. Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human Thioredoxin. at AA range: 52-101

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight:

  12kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  12 kD

• Subcellular Location:

  Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029) . Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054) . Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054) . Secreted by a leaderless secretory pathway (PubMed:1332947) . .

• Other Product Names:

  Thioredoxin (Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP)

• Gene ID (Human):

  7295

• SwissProt (Human):

  P10599