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Thrombospondin 4 rabbit pAb

CAT: 0855-ES8715-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8715-01Size:50 µL
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Background
Thrombospondin 4 (THBS4) Homo sapiens The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Description
Thrombospondin 4 (THBS4) Homo sapiens The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
UniProt
P35443
Swiss Prot
P35443
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 551-600
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix .
Other Product Names
Thrombospondin-4
Gene ID (Human)
7060

UniProtKB · P35443

Thrombospondin-4

TSP4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35443
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
THBS4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R909, Q86TG2
Protein keywords

Ligand

Calcium

Biological process

Cell adhesionTissue remodelingUnfolded protein response

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignal

Cellular component

Endoplasmic reticulumExtracellular matrixSarcoplasmic reticulumSecreted

Molecular function

Growth factorMitogen

Technical term

Proteomics identificationReference proteome

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