COL25A1 rabbit pAb

COL25A1 rabbit pAb

• Description: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
• Synonyms: COL25A1
• Gene ID: 84570
• UniProt: Q9BXS0
• Cellular Locus: Membrane ; Single-pass type II membrane protein. After proteolytic cleavage, CLAC is secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide from human protein at AA range: 101-150
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000, ELISA 1:10000-20000
• Molecular Weight: 64kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.