COL18A1 rabbit pAb

CAT: 0855-ES7622-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES7622-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Description
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
UniProt
P39060
Swiss Prot
P39060
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen alpha1 XVIII. AA range:1301-1350
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix . Secreted, extracellular space, extracellular matrix, basement membrane .; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane . Secreted .; [Endostatin]: Secreted . Secreted, extracellular space, extracellular matrix, basement membrane .
Other Product Names
COL18A1; Collagen alpha-1 (XVIII) chain
Gene ID (Human)
80781

Related Products

CatalogName
ES8757-01COL14A1 rabbit pAb
ES8550-01COL17A1 rabbit pAb
ES8871-01COL13A1 rabbit pAb
ES4756-01COL13A1 rabbit pAb
ES4757-01COL16A1 rabbit pAb
ES4758-01COL17A1 rabbit pAb
ES4752-01COL11A1 rabbit pAb
ES4753-01COL12A1 rabbit pAb
ES7478-01COL14A1 rabbit pAb
ES4759-01COL19A1 rabbit pAb

Alternative Products

CatalogName
E45R23574NCOL18A1 Rabbit pAb
E56G3875COL18A1 Rabbit Monoclonal Antibody
E43S49231COL18A1 Recombinant Rabbit mAb
APRab09175-01COL18A1 Rabbit Polyclonal Antibody
APR23574N-01COL18A1 Rabbit pAb (APR23574N)
TA356579Endostatin (COL18A1) Rabbit Polyclonal Antibody
PAV6186Rabbit Anti-COL18A1 Polyclonal Antibody
PA10784-01Rabbit Anti-Human COL18A1 pAb
abx355257Rabbit Endostatin (COL18A1) ELISA Kit
MBS8109413-01Anti-Col18a1 Antibody, Rabbit Polyclonal

Popular Products