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Perforin 1 rabbit pAb

CAT: 0855-ES8510-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8510-01Size:50 µL
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Background
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Product Name Alternative
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
UniProt
P14222
Swiss Prot
P14222
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500
Target
Perforin
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
61kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
61kD
Fragment
IgG
Subcellular Location
Cytolytic granule . Secreted. Cell membrane ; Multi-pass membrane protein . Endosome lumen . Stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell (PubMed:20038786) . Inserts into the cell membrane of target cells and forms pores (PubMed:20889983) . Membrane insertion and pore formation requires a major conformation change (PubMed:20889983) . May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (PubMed:20038786) . .
Other Product Names
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
Gene ID (Human)
5551

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