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CYFIP2 rabbit pAb

CAT: 0855-ES8500-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8500-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level) ., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.
Description
Disease: Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level). function: Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA. induction: By p53. RNA editing: Partially edited. Editing appears to be brain-specific. similarity: Belongs to the CYFIP family. subcellular location: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.
Product Name Alternative
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
UniProt
Q96F07
Swiss Prot
Q96F07
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Target
CYFIP2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
150+45kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
150+45kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity) . Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118) . .
Other Product Names
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Gene ID (Human)
26999

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