CYFIP2 rabbit pAb

• Background:

  Disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level) ., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.

• Description:

  Disease: Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level). function: Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA. induction: By p53. RNA editing: Partially edited. Editing appears to be brain-specific. similarity: Belongs to the CYFIP family. subcellular location: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.

• UniProt:

  Q96F07

• Swiss Prot:

  Q96F07

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight:

  150+45kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  150+45kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity) . Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118) . .

• Other Product Names:

  Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

• Gene ID (Human):

  26999