AMBRA1 rabbit pAb

AMBRA1 rabbit pAb

• Description: Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. similarity: Contains 3 WD repeats. subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.
• Synonyms: autophagy/beclin-1 regulator 1
• Gene ID: 55626
• UniProt: Q9C0C7
• Cellular Locus: Endoplasmic reticulum. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome. Mitochondrion. Cytoplasm, cytosol. Nucleus. Cell junction, focal adhesion. Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139). Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139). Partially localizes at mitochondria in normal conditions (PubMed:21358617). Localizes also to discrete punctae along the ciliary axoneme (By similarity)..
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic Peptide of AMBRA1
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000, ELISA 1:10000-20000
• Molecular Weight: 140kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.