AMBRA1 rabbit pAb

• Background:

  Function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation., similarity:Contains 3 WD repeats., subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

• Description:

  Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. similarity: Contains 3 WD repeats. subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

• UniProt:

  Q9C0C7

• Swiss Prot:

  Q9C0C7

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthetic Peptide of AMBRA1

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight:

  140kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  140kD

• Fragment:

  IgG

• Subcellular Location:

  Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome . Mitochondrion . Cytoplasm, cytosol . Nucleus . Cell junction, focal adhesion . Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139) . Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139) . Partially localizes at mitochondria in normal conditions (PubMed:21358617) . Localizes also to discrete punctae along the ciliary axoneme (By similarity) . .

• Other Product Names:

  Autophagy/beclin-1 regulator 1

• Gene ID (Human):

  55626