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AMBRA1 rabbit pAb

CAT: 0855-ES8480-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8480-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation., similarity:Contains 3 WD repeats., subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.
Description
Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. similarity: Contains 3 WD repeats. subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.
Product Name Alternative
Autophagy/beclin-1 regulator 1
UniProt
Q9C0C7
Swiss Prot
Q9C0C7
Reactivity
Human; Mouse
Immunogen
Synthetic Peptide of AMBRA1
Target
AMBRA1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
140kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
140kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome . Mitochondrion . Cytoplasm, cytosol . Nucleus . Cell junction, focal adhesion . Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139) . Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139) . Partially localizes at mitochondria in normal conditions (PubMed:21358617) . Localizes also to discrete punctae along the ciliary axoneme (By similarity) . .
Other Product Names
Autophagy/beclin-1 regulator 1
Gene ID (Human)
55626

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