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CD156c rabbit pAb

CAT: 0855-ES8368-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8368-02Size:100 µL
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Background
ADAM metallopeptidase domain 10 (ADAM10) Homo sapiens Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Description
ADAM metallopeptidase domain 10 (ADAM10) Homo sapiens Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016],
UniProt
O14672
Swiss Prot
O14672
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human CD156c.
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, axon . Cell projection, dendrite . Cell junction, adherens junction . Cytoplasm . Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894) . During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497) . The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011) . The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33
Other Product Names
ADAM10; KUZ; MADM; Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c
Gene ID (Human)
102

UniProtKB · O14672

Disintegrin and metalloproteinase domain-containing protein 10

ADA10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14672
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADAM10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ADAM 10
EC number
3.4.24.81
Processing
Precursor
Secondary accessions
B4DU28, Q10742, Q92650
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoplasmic vesicleGolgi apparatusMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc

Biological process

Notch signaling pathway

Domain

SH3-bindingSignalTransmembraneTransmembrane helix

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