CD166 rabbit pAb

• Background:

  This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

• Description:

  This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011],

• UniProt:

  Q13740

• Swiss Prot:

  Q13740

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the C-terminal region of human ALCAM. AA range:481-530

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IF; WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  IF: 1:50-200 Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  65kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  65kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) . Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938) . .; [Isoform 3]: Secreted .

• Other Product Names:

  ALCAM; MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD166

• Gene ID (Human):

  214