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Granuphilin rabbit pAb

CAT: 0855-ES8035-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Description
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010],
UniProt
Q96C24
Swiss Prot
Q96C24
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SYTL4. AA range:381-430
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
76kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
76kD
Fragment
IgG
Subcellular Location
Membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity) . .
Other Product Names
SYTL4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin
Gene ID (Human)
94121

UniProtKB · Q96C24

Synaptotagmin-like protein 4

SYTL4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96C24
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYTL4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmic vesicleMembrane

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Domain

RepeatZinc-finger