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TFIIIC90 rabbit pAb

CAT: 0855-ES8022-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8022-01Size:50 µL
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Background
Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., function:Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the TFIIIC subunit 4 family., subunit:Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
Description
Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone. function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the TFIIIC subunit 4 family. subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
Product Name Alternative
GTF3C4; General transcription factor 3C polypeptide 4; TF3C-delta; Transcription factor IIIC 90 kDa subunit; TFIIIC 90 kDa subunit; TFIIIC90; Transcription factor IIIC subunit delta
UniProt
Q9UKN8
Swiss Prot
Q9UKN8
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TF3C4. AA range:611-660
Target
TFIIIC90
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
95kD
Fragment
IgG
Subcellular Location
Nucleus.
Other Product Names
GTF3C4; General transcription factor 3C polypeptide 4; TF3C-delta; Transcription factor IIIC 90 kDa subunit; TFIIIC 90 kDa subunit; TFIIIC90; Transcription factor IIIC subunit delta
Gene ID (Human)
9329

UniProtKB · Q9UKN8

General transcription factor 3C polypeptide 4

TF3C4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UKN8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GTF3C4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.48
Processing
—
Secondary accessions
Q5VZJ7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

AcyltransferaseDNA-bindingTransferase

Cellular component

Nucleus

Biological process

Transcription

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