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RECK rabbit pAb

CAT: 0855-ES7751-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7751-01Size:50 µL
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Background
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Description
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
UniProt
O95980
Swiss Prot
O95980
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RECK. AA range:21-70
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor, GPI-anchor .
Other Product Names
RECK; ST15; Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; Suppressor of tumorigenicity 15 protein
Gene ID (Human)
8434

UniProtKB · O95980

Reversion-inducing cysteine-rich protein with Kazal motifs

RECK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95980
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RECK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hRECK
EC number
—
Processing
Precursor
Secondary accessions
B2RNS1, Q5W0K6, Q8WX37
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Molecular function

Protease inhibitorSerine protease inhibitor

Domain

RepeatSignal

Disease

Tumor suppressor

Biological process

Wnt signaling pathway

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