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RPA135 rabbit pAb

CAT: 0855-ES7737-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7737-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]) .[supplied by OMIM, Mar 2008]
Description
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]). [supplied by OMIM, Mar 2008],
UniProt
Q9H9Y6
Swiss Prot
Q9H9Y6
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human RPA135.
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
125kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
125kD
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Chromosome .
Other Product Names
POLR1B; DNA-directed RNA polymerase I subunit RPA2; RNA polymerase I subunit 2; DNA-directed RNA polymerase I 135 kDa polypeptide; RPA135
Gene ID (Human)
84172

UniProtKB · Q9H9Y6

DNA-directed RNA polymerase I subunit RPA2

RPA2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H9Y6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLR1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RNA polymerase I subunit 2
EC number
2.7.7.6
Processing
—
Secondary accessions
B7Z6Y7, B7Z823, F5GZX4, F8W898, Q2TAM4, Q585T5, Q6ZRR2, Q9H9D3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeDNA-directed RNA polymeraseNucleus

Disease

Disease variant

Ligand

MagnesiumMetal-bindingZinc

Molecular function

NucleotidyltransferaseTransferase

PTM

Phosphoprotein

Biological process

Transcription

Domain

Zinc-finger

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