Products for Research Use Only
RegisterLogin

Calpain 2 rabbit pAb

CAT: 0855-ES7658-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES7658-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Description
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
UniProt
P17655
Swiss Prot
P17655
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Calpain 2. AA range:305-354
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca (2+) binding.
Other Product Names
CAPN2; CANPL2; Calpain-2 catalytic subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; Millimolar-calpain; M-calpain
Gene ID (Human)
824

UniProtKB · P17655

Calpain-2 catalytic subunit

CAN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17655
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAPN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.53
Processing
Precursor
Secondary accessions
A6NDG7, B7ZA96, E7ES58, Q16738, Q6PJT3, Q8WU26, Q9HBB1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationAutocatalytic cleavageIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCytoplasmMembrane

Molecular function

HydrolaseProteaseThiol protease

Domain

Repeat

Related Products

CatalogName
ES20175-01Calpain 2 (Phospho Ser50) rabbit pAb
ES1831-01Calpain 11 rabbit pAb
ES1832-01Calpain 12 rabbit pAb
ES4603-01Calpain 10 rabbit pAb
ES4550-01Calpain 9 rabbit pAb
ES1833-01Calponin 2 rabbit pAb
EA268-01CaVα2δ2 Rabbit pAb
ES20792-01CaVα2δ2 rabbit pAb
ES3631-01Tra-2α rabbit pAb
ES3954-01CYP11B1/2 rabbit pAb

Alternative Products

CatalogName
TA308681Rabbit Polyclonal antibody to Calpain 5 (calpain 5)
APA5006-01Calpain S1 Rabbit pAb
APA1902-01Calpain 2 Rabbit pAb
MBS9468416-01Calpain 1 Rabbit mAb
A21673-01Calpain 1 Rabbit pAb
AB101082Calpain S1 Rabbit mAb
59517Calpain 2 Rabbit mAb
MBS225086-01Rabbit anti CALPAIN-1
GTR18598055-01Calpain 5 Rabbit pAb
MBS225087-01Rabbit anti CALPAIN-2

Popular Products