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Calpain 10 rabbit pAb

CAT: 0855-ES4603-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq
Description
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq,
Product Name Alternative
CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10
UniProt
Q9HC96
Swiss Prot
Q9HC96
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human Calpain 10.
Target
Calpain 10
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
75kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
75kD
Fragment
IgG
Subcellular Location
Intracellular, cell, mitochondrion, cytosol, plasma membrane
Other Product Names
CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10
Gene ID (Human)
11132

UniProtKB · Q9HC96

Calpain-10

CAN10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HC96
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAPN10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.-
Processing
—
Secondary accessions
A8MVS7, Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Diabetes mellitus

Molecular function

HydrolaseProteaseThiol protease

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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