Tuberin (phospho Tyr1571) rabbit pAb

• Background:

  Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Description:

  Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• Synonyms:

  TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein

• Gene ID:

  7249

• UniProt:

  P49815

• Cellular Locus:

  Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human TSC2 around the phosphorylation site of Tyr1571. AA range:1537-1586

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight:

  170kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  170 kD

• Subcellular Location:

  Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

• Other Product Names:

  TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein

• Gene ID (Human):

  7249

• SwissProt (Human):

  P49815