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Tuberin rabbit pAb

CAT: 0855-ES7452-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7452-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Description
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
UniProt
P49815
Swiss Prot
P49815
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Tuberin. AA range:947-996
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
210kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
210kD
Fragment
IgG
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Other Product Names
TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein
Gene ID (Human)
7249

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