TLE2 rabbit pAb

• Background :

  Function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES., similarity:Belongs to the WD repeat Groucho/TLE family., similarity:Contains 6 WD repeats., subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5., tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.

• Description :

  Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. similarity: Belongs to the WD repeat Groucho/TLE family. similarity: Contains 6 WD repeats. subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5. tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.

• UniProt :

  Q04725

• Swiss Prot :

  Q04725

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human TLE2. AA range:211-260

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  110kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  110kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus.

• Other Product Names :

  TLE2; Transducin-like enhancer protein 2; Enhancer of split groucho-like protein 2; ESG2

• Gene ID (Human) :

  7089