TLE4 rabbit pAb

• Background:

  Caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation., function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES., similarity:Belongs to the WD repeat Groucho/TLE family., similarity:Contains 7 WD repeats., subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2., tissue specificity:In all tissues examined, mostly in brain, and muscle.

• Description:

  Caution: Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed: 15302935) would require further confirmation. function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. similarity: Belongs to the WD repeat Groucho/TLE family. similarity: Contains 7 WD repeats. subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. tissue specificity: In all tissues examined, mostly in brain, and muscle.

• UniProt:

  Q04727

• Swiss Prot:

  Q04727

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human TLE4. AA range:161-210

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  83kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  83kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus.

• Other Product Names:

  TLE4; KIAA1261; Transducin-like enhancer protein 4

• Gene ID (Human):

  7091