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Spectrin β II rabbit pAb

CAT: 0855-ES7262-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7262-01Size:50 µL
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Background
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q01082
Swiss Prot
Q01082
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SPTBN1. AA range:651-700
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
275kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
275kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, M line . Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. .; [Isoform 2]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Other Product Names
SPTBN1; SPTB2; Spectrin beta chain; non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
Gene ID (Human)
6711

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