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CRABP-II rabbit pAb

CAT: 0855-ES2042-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2042-01Size:50 µL
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Background
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Description
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010],
UniProt
P29373
Swiss Prot
P29373
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CRABP2. AA range:41-90
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
16kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
16kD
Fragment
IgG
Subcellular Location
Cytoplasm. Endoplasmic reticulum. Nucleus. Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Other Product Names
CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II
Gene ID (Human)
1382

UniProtKB · P29373

Cellular retinoic acid-binding protein 2

RABP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P29373
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CRABP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R4Z8, D3DVC5, F1T098, Q6ICN6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

CytoplasmEndoplasmic reticulumNucleus

PTM

Isopeptide bondUbl conjugation

Ligand

Retinol-bindingVitamin A

Biological process

Transport

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