BID (phospho Ser78) rabbit pAb

BID (phospho Ser78) rabbit pAb

• Description: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers Cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008],
• Synonyms: BID; BH3-interacting domain death agonist; p22 BID; BID
• Gene ID: 637
• UniProt: P55957
• Cellular Locus: Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. When uncleaved, it is predominantly cytoplasmic..; [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Translocates to mitochondria as an integral membrane protein..; [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Associated with the mitochondrial membrane..; [Isoform 1]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 2]: Mitochondrion membrane. A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively..
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: The antiserum was produced against synthesized peptide derived from human BID around the phosphorylation site of Ser78. AA range:44-93
• Clonality: Polyclonal
• Validated Applications: IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.