Rb (phospho Ser249) rabbit pAb
CAT:
855-ES7000-01
Size:
50 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rb (phospho Ser249) rabbit pAb
- Description: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
- Synonyms: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
- Gene ID: 5925
- UniProt: P06400
- Cellular Locus: Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization..
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270
- Clonality: Polyclonal
- Validated Applications: WB, ELISA, IHC
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.