C-Jun (Phospho Ser249) rabbit pAb

• Background:

  Function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'., PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC., similarity:Belongs to the bZIP family., similarity:Belongs to the bZIP family. Jun subfamily., similarity:Contains 1 bZIP domain., subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity) . Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

• Description:

  Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. Jun subfamily. similarity: Contains 1 bZIP domain. subunit: Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

• Synonyms:

  Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39)

• Gene ID:

  3725

• UniProt:

  P05412

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human c-Jun (Phospho Ser249)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight:

  39-42kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  39 - 42 kD

• Subcellular Location:

  Nucleus.

• Other Product Names:

  Transcription factor AP-1 (Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39)

• Gene ID (Human):

  3725

• SwissProt (Human):

  P05412