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Rb (phospho Ser780) rabbit pAb

CAT: 0855-ES1400-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1400-01Size:50 µL
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Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Product Name Alternative
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
UniProt
P06400
Swiss Prot
P06400
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser780. AA range:751-800
Target
Rb
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
106kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
106kD
Fragment
IgG
Subcellular Location
Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
Other Product Names
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Gene ID (Human)
5925

UniProtKB · P06400

Retinoblastoma-associated protein

RB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06400
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K5E3, P78499, Q5VW46, Q8IZL4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Biological process

Cell cycleHost-virus interactionTranscriptionTranscription regulation

Molecular function

Chromatin regulatorDNA-bindingRepressor

Cellular component

CytoplasmNucleus

Disease

Disease variantTumor suppressor

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