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Rad21 rabbit pAb

CAT: 0855-ES6968-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6968-01Size:50 µL
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Background
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008],
UniProt
O60216
Swiss Prot
O60216
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD21. AA range:521-570
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
72kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
72kD
Fragment
IgG
Subcellular Location
[Double-strand-break repair protein rad21 homolog]: Nucleus . Nucleus matrix . Chromosome . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . Associates with chromatin (PubMed:11590136, PubMed:11073952) . Before prophase, scattered along chromosome arms (PubMed:11073952) . During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760) . A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732) . .; [64-kDa C-terminal product]: Cytoplasm, cytosol . Nucleus .
Other Product Names
RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; Nuclear matrix protein 1; NXP-1; SCC1 homolog
Gene ID (Human)
5885

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