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AVP Receptor V2 rabbit pAb

CAT: 0855-ES6726-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus
Description
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus
Product Name Alternative
AVPR2; ADHR; DIR; DIR3; V2R; Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
UniProt
P30518
Swiss Prot
P30518
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human AVPR2. AA range:72-121
Target
AVP Receptor V2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Other Product Names
AVPR2; ADHR; DIR; DIR3; V2R; Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
Gene ID (Human)
554

UniProtKB · P30518

Vasopressin V2 receptor

V2R_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30518
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AVPR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
V2R
EC number
—
Processing
—
Secondary accessions
C5HF20, O43192, Q3MJD3, Q9UCV9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Diabetes insipidusDisease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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