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Plasminogen receptor rabbit pAb

CAT: 0855-ES8519-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8519-01Size:50 µL
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Background
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
Description
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
Product Name Alternative
Plasminogen receptor (KT) (Plg-R (KT) )
UniProt
Q9HBL7
Swiss Prot
Q9HBL7
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50
Target
Plasminogen receptor
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
17kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
17kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. .
Other Product Names
Plasminogen receptor (KT) (Plg-R (KT) )
Gene ID (Human)
55848

UniProtKB · Q9HBL7

Plasminogen receptor (KT)

PLRKT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HBL7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLGRKT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Plg-R(KT)
EC number
—
Processing
—
Secondary accessions
B2R6W0, Q9NZ44
Protein keywords

Cellular component

Cell membraneMembrane

Biological process

ChemotaxisInflammatory responsePlasminogen activation

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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