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DNA pol δ cat rabbit pAb

CAT: 0855-ES6643-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6643-01Size:50 µL
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Background
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
Description
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012],
Product Name Alternative
POLD1; POLD; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125
UniProt
P28340
Swiss Prot
P28340
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human POLD1. AA range:1051-1100
Target
DNA pol δ cat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
110 124kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110 124kD
Fragment
IgG
Subcellular Location
Nucleus . Colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739) . After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex (PubMed:20227374, PubMed:22801543) . .
Other Product Names
POLD1; POLD; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125
Gene ID (Human)
5424

UniProtKB · P28340

DNA polymerase delta catalytic subunit

DPOD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28340
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.7.7
Processing
—
Secondary accessions
Q8NER3, Q96H98
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-bindingZinc

Disease

Disease variant

Biological process

DNA damageDNA excisionDNA repairDNA replication

Molecular function

DNA-bindingDNA-directed DNA polymeraseExonucleaseHydrolaseNucleaseNucleotidyltransferaseTransferase

PTM

Isopeptide bondMethylationUbl conjugation

Cellular component

Nucleus

Domain

Zinc-finger

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