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DNA pol ε A rabbit pAb

CAT: 0855-ES6644-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6644-01Size:50 µL
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Background
DNA polymerase epsilon, catalytic subunit (POLE) Homo sapiens This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]
Description
DNA polymerase epsilon, catalytic subunit (POLE) Homo sapiens This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013],
UniProt
Q07864
Swiss Prot
Q07864
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human POLE1. AA range:1261-1310
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus.
Other Product Names
POLE; POLE1; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A
Gene ID (Human)
5426

UniProtKB · Q07864

DNA polymerase epsilon catalytic subunit A

DPOE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q07864
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLE
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.7.7
Processing
—
Secondary accessions
Q13533, Q86VH9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-bindingZinc

Disease

Disease variant

Biological process

DNA damageDNA repairDNA replication

Molecular function

DNA-bindingDNA-directed DNA polymeraseHydrolaseNucleotidyltransferaseTransferase

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

Zinc-finger

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