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Plasminogen rabbit pAb

CAT: 0855-ES6617-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6617-01Size:50 µL
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Background
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Description
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
UniProt
P00747
Swiss Prot
P00747
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Plasminogen.
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
90kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
90kD
Fragment
IgG
Subcellular Location
Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Other Product Names
PLG; Plasminogen
Gene ID (Human)
5340

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