Malantide

CAT: 0804-HY-P1597-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-P1597-02Size:10 mg

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Description

Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide is also an efficient substrate for PKC with a Km of 16 μM[2].

CAS Number

86555-35-3

UNSPSC

12352209

Target

PKA; PKC

Type

Peptides

Related Pathways

Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Malantide.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C72H124N22O21

Molecular Weight

1633.89

References & Citations

[1]Murray KJ, et al. Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues. Biochem J. 1990 May 1;267 (3) :703-8.|[2]Z H Zhao, et al. Characterization of a New Substrate for Protein Kinase C: Assay by Continuous Fluorometric Monitoring and High Performance Liquid Chromatography. Biochem Biophys Res Commun. 1991 May 15;176 (3) :1454-61.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

Malantide

tetradecapeptide derived from the phosphorylation site of the beta subunit of phosphorylase kinase; used to measure the cyclic AMP-dependent protein kinase activity in various tissues; amino acid sequence given in first source

CAS Number	86555-35-3
PubChem CID	135765
IUPAC Name	(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-methylpentanoic acid
Molecular Formula	C72H124N22O21
Molecular Weight	1633.9
XLogP	-9.9
Topological Polar Surface Area	732
Hydrogen Bond Donor Count	25
Hydrogen Bond Acceptor Count	26
Rotatable Bond Count	55
Heavy Atom Count	115
Formal Charge	0
Complexity	3250

SMILES

CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCN=C(N)N)N

InChI

InChI=1S/C72H124N22O21/c1-8-39(6)56(70(114)115)92-62(106)45(18-10-12-28-74)85-63(107)48(32-37(2)3)88-66(110)52-20-15-31-94(52)69(113)47(25-26-54(100)101)87-64(108)49(33-41-21-23-42(98)24-22-41)89-67(111)55(38(4)5)91-65(109)51(36-96)83-53(99)34-82-59(103)50(35-95)90-61(105)46(19-14-30-81-72(78)79)84-60(104)44(17-9-11-27-73)86-68(112)57(40(7)97)93-58(102)43(75)16-13-29-80-71(76)77/h21-24,37-40,43-52,55-57,95-98H,8-20,25-36,73-75H2,1-7H3,(H,82,103)(H,83,99)(H,84,104)(H,85,107)(H,86,112)(H,87,108)(H,88,110)(H,89,111)(H,90,105)(H,91,109)(H,92,106)(H,93,102)(H,100,101)(H,114,115)(H4,76,77,80)(H4,78,79,81)/t39-,40+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-,57-/m0/s1

InChIKey

COABRICCWCYCPI-ZYLNUDMXSA-N

Chemical Structure

2D Structure

CAS: 86555-35-3

CID: 135765

Formula: C72H124N22O21

MW: 1633.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1633.9
XLogP3	-9.9
Hydrogen Bond Donor Count	25
Hydrogen Bond Acceptor Count	26
Rotatable Bond Count	55
Exact Mass	1632.93113905
Monoisotopic Mass	1632.93113905
Topological Polar Surface Area	732 Å²
Heavy Atom Count	115
Formal Charge	0
Complexity	3250
Isotope Atom Count	0
Defined Atom Stereocenter Count	15
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
C06893-5mg	Malantide
A23132-1	Malantide 1mg
350256	Malantide Peptide
A23132-10	Malantide 10mg
T75989-01	Malantide TFA

Malantide

Chemical Information

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