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NuMA rabbit pAb

CAT: 0855-ES6436-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6436-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Description
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],
UniProt
Q14980
Swiss Prot
Q14980
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human NUMA1. AA range:334-383
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
240kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
240kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleoplasm . Nucleus matrix . Chromosome . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cell cortex . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Lateral cell membrane . Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:1541636, PubMed:10811826) . The localization to the spindle poles is regulated by AAAS (PubMed:26246606) . In interphase, resides in the nuclear matrix (PubMed:1541630, PubMed:1541636, PubMed:23921553) . In prophase, restricted to the interchromatin or condensed chromosome space (PubMed:10811826) . In prometaphase, after nuclear envelope disassembly, forms aggregates
Other Product Names
NUMA1; NUMA; Nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigen
Gene ID (Human)
4926

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