NUMB rabbit pAb

• Background:

  The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

• Description:

  The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

• UniProt:

  P49757

• Swiss Prot:

  P49757

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from the Internal region of human NUMB.

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IF/ICC 1:100-500; ELISA 1:5000-20000

• Molecular Weight:

  70kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  70kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .

• Other Product Names:

  NUMB; Protein numb homolog; h-Numb; Protein S171

• Gene ID (Human):

  8650