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ROR2 rabbit pAb

CAT: 0855-ES6434-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6434-02Size:100 µL
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Background
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008],
UniProt
Q01974
Swiss Prot
Q01974
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from ROR2 . at AA range: 450-530
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
ROR2; NTRKR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase; receptor-related 2
Gene ID (Human)
4920

UniProtKB · Q01974

Tyrosine-protein kinase transmembrane receptor ROR2

ROR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01974
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ROR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q59GF5, Q5SPI5, Q9HAY7, Q9HB61
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoproteinMethylationPhosphoproteinSulfation

Domain

Immunoglobulin domainKringleSignalTransmembraneTransmembrane helix

Biological process

Wnt signaling pathway

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