MLK1/2 (phospho Thr312/266) rabbit pAb
CAT:
855-ES6249-02
Size:
100 μL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MLK1/2 (phospho Thr312/266) rabbit pAb
- Description: Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. function: Activates the JUN N-terminal pathway. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 SH3 domain. subunit: Homodimer. tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
- Synonyms: MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST
- Gene ID: 4293/4294
- UniProt: P80192/Q02779
- Cellular Locus: Intracellular,integral component of membrane,
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: The antiserum was produced against synthesized peptide derived from human MLK1/2 around the phosphorylation site of Thr312/266. AA range:281-330
- Clonality: Polyclonal
- Validated Applications: IHC, IF, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.