MLK1/2 rabbit pAb

CAT: 0855-ES6250-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6250-01Size:50 µL
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation., function:Activates the JUN N-terminal pathway., PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH3 domain., subunit:Homodimer., tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. function: Activates the JUN N-terminal pathway. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 SH3 domain. subunit: Homodimer. tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
UniProt
P80192/Q02779
Swiss Prot
P80192/Q02779
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MLK1/2. AA range:281-330
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Intracellular, integral component of membrane
Other Product Names
MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST
Gene ID (Human)
4293/4294

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