AR (phospho Ser650) rabbit pAb

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Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoform

Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

UniProt

P10275

Swiss Prot

P10275

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human Androgen Receptor around the phosphorylation site of Ser650. AA range:621-670

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737) . Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .

Other Product Names

AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4

Gene ID (Human)

367

UniProtKB · P10275

Androgen receptor

ANDR_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P10275
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: AR
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A0A0B4J1T2, A2RUN2, B1AKD7, C0JKD3, C0JKD4, E7EVX6, Q9UD95

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

Disease

Disease variantNeurodegenerationPseudohermaphroditism

PTM

Isopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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Alternative Products

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APRab04251-01	AR (phospho Ser650) Rabbit Polyclonal Antibody
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GTR17728365-01	Phospho-LLGL1 + LLGL2 (Ser650+Ser654) Rabbit Polyclonal Antibody
GTR17725770	Phospho-Androgen Receptor (Ser650) Rabbit Polyclonal Antibody (FITC)
GTR17807434	Phospho-Androgen Receptor (Ser650) Rabbit Polyclonal Antibody (Cy3)
GTR18252373	Phospho-Androgen Receptor (Ser650) Rabbit Polyclonal Antibody (PerCP)
GTR18252370	Phospho-Androgen Receptor (Ser650) Rabbit Polyclonal Antibody (BF350)
GTR18252363	Phospho-Androgen Receptor (Ser650) Rabbit Polyclonal Antibody (BF680)