Products for Research Use Only
RegisterLogin

AR rabbit pAb

CAT: 0855-ES5938-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES5938-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoform
Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
UniProt
P10275
Swiss Prot
P10275
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human c-ternal Androgen Receptor. AA range:621-670
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
99kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
99kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737) . Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .
Other Product Names
AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Gene ID (Human)
367

Related Products

CatalogName
ES1712-01AR-β1 rabbit pAb
ES4864-01AR-α1D rabbit pAb
ES4927-01AR-β3 rabbit pAb
ES1691-01AR α2C rabbit pAb
ES4899-01AR α2B rabbit pAb
ES4879-01AR-α1A rabbit pAb
ES4894-01AR-α2A rabbit pAb
ES4873-01AR-α1B rabbit pAb
ES1713-01AR-β2 rabbit pAb
ES4893-01AR α2A rabbit pAb

Alternative Products

CatalogName
RTR015Rabbit-to-Rabbit Blocking Reagent
AR05252PU-NRabbit IgG Rabbit Protein
AR05110PU-NRabbit IgM Rabbit Protein
NBP1-71681Rabbit Normal Rabbit Serum
OORA00605-100MLRabbit
KA2017Rabbit Rabbit IgG ELISA Kit
MBS9518120-01ATG4c Rabbit Rabbit Polyclonal Antibody
MBS9518118-01ATG4a Rabbit Rabbit Polyclonal Antibody
MBS9512780-01JAK2 Rabbit Rabbit Polyclonal Antibody
MBS9512768-01VEGF Rabbit Rabbit Polyclonal Antibody

Popular Products