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Insulin R rabbit pAb

CAT: 0855-ES5912-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Description
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
UniProt
P06213
Swiss Prot
P06213
Reactivity
Human; Rat; Mouse; ; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human IR. AA range:1326-1375
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
155kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
155kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Late endosome . Lysosome . Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception. .
Other Product Names
INSR; Insulin receptor; IR; CD antigen CD220
Gene ID (Human)
3643

UniProtKB · P06213

Insulin receptor

INSR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06213
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INSR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IR
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q17RW0, Q59H98, Q9UCB7, Q9UCB8, Q9UCB9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Carbohydrate metabolism

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Disease

Diabetes mellitusDisease variant

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

RepeatSignalTransmembraneTransmembrane helix

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