X11β rabbit pAb

CAT: 0855-ES5761-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES5761-01Size:50 µL
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Background
Amyloid beta precursor protein binding family A member 2 (APBA2) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP) . It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Amyloid beta precursor protein binding family A member 2 (APBA2) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q99767
Swiss Prot
Q99767
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human APBA2. AA range:371-420
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
83kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
83kD
Fragment
IgG
Subcellular Location
Plasma membrane, synaptic vesicle
Other Product Names
APBA2; MINT2; X11L; Amyloid beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2
Gene ID (Human)
321

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