Huntingtin rabbit pAb

CAT: 0855-ES5728-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES5728-01Size:50 µL

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Background

Huntingtin (HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel

Description

Huntingtin (HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13. 7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10. 3 kb is more widel

UniProt

P42858

Swiss Prot

P42858

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Huntingtin. AA range:387-436

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

[Huntingtin]: Cytoplasm . Nucleus . Early endosome . The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337) . Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778) . .; [Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome .

Other Product Names

HTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein

Gene ID (Human)

3064

UniProtKB · P42858

Huntingtin

HD_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P42858
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: HTT
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q9UQB7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationLipoproteinMyristatePhosphoproteinUbl conjugation

Biological process

Apoptosis

Cellular component

CytoplasmCytoplasmic vesicleEndosomeNucleus

Disease

Disease variantIntellectual disabilityNeurodegeneration

Domain

Repeat

Coding sequence diversity

Triplet repeat expansion

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APA4294-01	Huntingtin Rabbit pAb
AB102776	Huntingtin Rabbit mAb
GTR18218096-01	Rabbit Huntingtin Antibody