GRK 4 rabbit pAb

• Background:

  This gene encodes a member of the guanine nucleotide-binding protein (G protein) -coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

• Description:

  This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],

• UniProt:

  P32298

• Swiss Prot:

  P32298

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from GRK 4 . at AA range: 10-90

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Storage Conditions:

  -20°C/1 year

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm. Cytoplasm, cell cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

• Other Product Names:

  GRK4; GPRK2L; GPRK4; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; ITI1

• Gene ID (Human):

  2868