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GlyRβ rabbit pAb

CAT: 0855-ES5566-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5566-01Size:50 µL
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Background
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Description
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Product Name Alternative
GLRB; Glycine receptor subunit beta; Glycine receptor 58 kDa subunit
UniProt
P48167
Swiss Prot
P48167
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human GLRB. AA range:211-260
Target
GlyRβ
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
56kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
56kD
Fragment
IgG
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523) . Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. .
Other Product Names
GLRB; Glycine receptor subunit beta; Glycine receptor 58 kDa subunit
Gene ID (Human)
2743

UniProtKB · P48167

Glycine receptor subunit beta

GLRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48167
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GLRB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K3K2, D3DP23, F5GWE1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmMembranePostsynaptic cell membraneSynapse

Ligand

Chloride

Molecular function

Chloride channelIon channelLigand-gated ion channelReceptor

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Ion transportTransport

Domain

SignalTransmembraneTransmembrane helix

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