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INPP5J rabbit pAb

CAT: 0855-ES5542-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5542-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:1D-myo-inositol 1,3,4,5-tetrakisphosphate + H (2) O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate., catalytic activity:D-myo-inositol 1,4,5-trisphosphate + H (2) O = myo-inositol 1,4-bisphosphate + phosphate., domain:The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein., function:Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles., PTM:Phosphorylated at Ser/Thr residues., similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family., subcellular location:Predominantly localized to membrane ruffles.
Description
Catalytic activity: 1D-myo-inositol 1, 3, 4, 5-tetrakisphosphate + H (2)O = 1D-myo-inositol 1, 3, 4-trisphosphate + phosphate. Catalytic activity: D-myo-inositol 1, 4, 5-trisphosphate + H (2)O = myo-inositol 1, 4-bisphosphate + phosphate. Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein. function: Inositol 5-phosphatase, which converts inositol 1, 4, 5-trisphosphate to inositol 1, 4-bisphosphate. Also converts phosphatidylinositol 4, 5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate to inositol 1, 3, 4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. PTM: Phosphorylated at Ser/Thr residues. similarity: Belongs to the inositol-1, 4, 5-trisphosphate 5-phosphatase type II family. subcellular location: Predominantly localized to membrane ruffles.
UniProt
Q15735
Swiss Prot
Q15735
Reactivity
Human; Rat
Immunogen
Synthesized peptide derived from INPP5J . at AA range: 850-930
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Predominantly localized to membrane ruffles. .
Other Product Names
INPP5J; PIB5PA; PIPP; Phosphatidylinositol 4; 5-bisphosphate 5-phosphatase A; Inositol polyphosphate 5-phosphatase J
Gene ID (Human)
27124

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