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SENP3 rabbit pAb

CAT: 0855-ES5470-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5470-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]) .[supplied by OMIM, Jun 2009]
Description
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al. 2006 [PubMed 16738315]). [supplied by OMIM, Jun 2009],
UniProt
Q9H4L4
Swiss Prot
Q9H4L4
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SENP3. AA range:10-59
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
80kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
80kD
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224) . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity) . .
Other Product Names
SENP3; SSP3; SUSP3; Sentrin-specific protease 3; SUMO-1-specific protease 3; Sentrin/SUMO-specific protease SENP3
Gene ID (Human)
26168

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