SENP5 rabbit pAb

• Background:

  The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]) .[supplied by OMIM, Jun 2009]

• Description:

  The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al. 2006 [PubMed 16738315]). [supplied by OMIM, Jun 2009],

• UniProt:

  Q96HI0

• Swiss Prot:

  Q96HI0

• Reactivity:

  Human; Mouse; Monkey

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human SENP5. AA range:651-700

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  86kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  86kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus, nucleolus .

• Other Product Names:

  SENP5; FKSG45; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5

• Gene ID (Human):

  205564